Promethazine is metabolized from the liver to several different compounds; the sulfoxides of promethazine and N-demethylpromethazine are the predominant metabolites appearing from the urine.
Promethazine HCl Oral Alternative is contraindicated in comatose states, As well as in folks identified to generally be hypersensitive or to obtain experienced an idiosyncratic response to promethazine or to other phenothiazines.
Warning really should be exercised when administering promethazine to pediatric patients 2 many years of age and more mature. It is recommended that the bottom effective dose of promethazine be used in pediatric people 2 yrs of age and more mature and concomitant administration of other medication with respiratory depressant effects be avoided.
Promethazine hydrochloride takes place as being a white to faint yellow, virtually odorless, crystalline powder which gradually oxidizes and turns blue on prolonged publicity to air.
The combination of promethazine hydrochloride and codeine phosphate is contraindicated in pediatric patients under six years of age. Concomitant administration of promethazine items with other respiratory depressants has an Affiliation with respiratory depression, and often Demise, in pediatric individuals.
Head Damage And Improved Intracranial Strain: The respiratory-depressant outcomes of narcotic analgesics as well as their capacity to elevate cerebrospinal fluid force can be markedly exaggerated from the presence of head personal injury, intracranial lesions or maybe a preexisting boost in intracranial strain.
Lessen Seizure Threshold - Promethazine may perhaps lower seizure threshold. It should be made use of with caution in persons with seizure Ailments or in people who're employing concomitant remedies, for example narcotics or neighborhood anesthetics, which can also influence seizure threshold.
Excessively significant dosages of antihistamines, which includes Promethazine HCl Oral Resolution, in pediatric clients might bring about sudden Loss of life (see OVERDOSAGE). Hallucinations and convulsions have transpired with therapeutic doses and overdoses of Promethazine in pediatric people. In pediatric patients who're acutely sick connected with dehydration, There may be an elevated susceptibility to dystonias with the use of Promethazine HCl.
Sedation This product relieves apprehension and induces a quiet rest from which the individual might be easily aroused.
The respiratory melancholy will involve a discount while in the responsiveness from the Mind stem respiratory facilities to the two boosts in carbon dioxide tension also to electrical check here stimulation.
The effect of promethazine and/or codeine on afterwards growth and enhancement from the new child is mysterious.
Stimulation may very well be obvious, specifically in little ones and geriatric individuals. Convulsions may perhaps seldom manifest. A paradoxical-kind response has been noted in kids getting solitary doses of seventy five mg to one hundred twenty five mg orally, characterised by hyperexcitability and nightmares.
Stimulation can be evident, especially in youngsters and geriatric patients. Convulsions may perhaps seldom take place. A paradoxical reaction continues to be claimed in youngsters getting one doses of seventy five mg to 125 mg orally, characterized by hyperexcitability and nightmares.
Location the mixture inside a container like a sealed plastic bag and throw it absent while in the family trash. It's also possible to stick to your state or community guidelines regarding how to safely toss away Promethazine Hydrochloride and Codeine Phosphate Oral Solution.